Senior Scientist I, Molecular Biology/Microbiology

We are seeking a Senior Scientist I with a background in molecular biology and/or microbiology to join our peptide display hit generation team. In this role, you will:

• Lead and manage technology development projects and therapeutic peptide hit generation efforts.
• Utilize phage-display and/or mRNA-display peptide technologies, including the design and generation of peptide display libraries, screening against therapeutic targets, and identification and maturation of pharmaceutically relevant hits.
• Leverage our innovative peptide microarray platform to accelerate hit identification and maturation from peptide display campaigns.

This position offers the opportunity to play a key role in discovering impactful peptide therapeutics within a collaborative and innovative team.

Responsibilities:

• Lead the development of in-house peptide display workflows (mRNA-display and/or phage-display) utilizing our proprietary peptide microarray platform to accelerate hit identification. Responsibilities include designing and generating display libraries, screening peptide libraries against therapeutic targets, performing next-generation sequencing, and conducting large-scale data analysis.
• Explore and assess advanced technologies for modifying peptide display libraries, such as chemical modification and incorporation of non-canonical amino acids.
• Use proprietary data analysis tools to efficiently analyze next-generation sequencing data and other large-scale datasets derived from peptide display libraries.
• Routinely demonstrate scientific initiative and creativity in research and development activities.
• Highly autonomous in performing laboratory research or method development, requiring only minimal direction from or interaction with supervisor.
• Formulate conclusions and design follow-on experiments based on multidisciplinary data.
• Initiate new areas of investigation that are scientifically meaningful and can be incorporated into a research or development plan.
• Primary author of publications, presentations, regulatory documents, and/or primary inventor of patents.
• Effectively communicate results and conclusions to a wide range of target audiences.
• Demonstrate high proficiency across wide range of relevant techniques/technologies.
• Maintain a high level of efficiency and productivity. Adhere to timelines.
• Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, and controlled drug and radioactive compounds where applicable.

Required:

• Bachelor’s Degree and 10 years of experience, Master’s Degree and 8 years of experience, PhD and no experience necessary. Degree(s) should be in Molecular Biology, Microbiology, Biochemistry, Chemical and Biological Engineering, or other relevant fields.
• Thorough knowledge of Chemical Biology principles as they relate to the structure and function of peptides, proteins, and other biomolecules
• Experience with mRNA-display and/or phage-display libraries, including the design and generation of libraries, screening processes, and subsequent data analysis.
• Proficiency in generating next-generation sequencing (NGS) libraries and analyzing the resulting sequencing datasets.
• Coding skills relevant to data science (e.g., Python) or a demonstrated willingness to learn such skills.
• Demonstrated ability to learn, understand and master new experimental techniques.
• Ability to multitask and work within timelines.
• Effective writer and communicator of research

Preferred:

• Experience with incorporation of non-canonical amino acids in mRNA-Display or Phage-Display libraries
• Experience in peptide therapeutics discovery and development
• Experience with automation for scaling molecular biology/microbiology workflows