Senior Scientist I, Pipeline Development & SAR Optimization

At AbbVie, we are dedicated to solving some of the world’s most complex and serious diseases. Our mission is to develop and deliver advanced therapeutics that change lives. We are looking for talented, passionate, and driven individuals to join our Biotherapeutics and Genetic Medicine (BGM) team. As a Senior Scientist in our siRNA group, you will be part of an innovative team focused on advancing RNA-based therapies that have the potential to revolutionize patient care.

AbbVie is looking for a Senior Scientist I to join our siRNA group within the Biotherapeutics and Genetic Medicine (BGM) department. This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to oligonucleotide therapeutics. The successful candidate will drive scientific innovation, identify new methods and techniques, and collaborate across functions to support the development of novel RNA-based therapies.

Responsibilities

• Lead research efforts within a cross-functional team to advance new therapeutic targets for siRNA-based pipeline development.
• Design and execute in vitro and in vivo proof-of-concept studies to evaluate siRNA library and characterize lead compounds for the target engagement and therapeutic benefits.
• Design and execute structure-activity-relationship (SAR) studies for lead optimization, including optimization of siRNA sequence, chemical modification patterns, conjugation sites and linkers, etc.
• Provide scientific leadership and expertise in candidate nomination and pipeline development.
• Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor.
• Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions.
• Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization.
• Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications.
• Mentor and support junior scientists within the team.

• BS, MS, or PhD in chemistry, molecular biology, biochemistry, or related field with typically 10+ years (BS), 8+ years (MS), or 0-3 years (PhD) of experience.
• Demonstrated expertise in siRNA therapeutics, including library design, screening and characterization of SAR.
• Demonstrated expertise for siRNA candidate nomination and pipeline development.
• Extensive hands-on experience and techniques for molecular and RNA biology, including cell culture, RNA extraction, RNA quantification (RT-PCR, qPCR, ddPCR), next-generation sequencing (NGS) library preparation, protein assays (ELISA, Western Blot, JESS), flow cytometry and other biomarker quantification.
• Experience in assay development and high-throughput screening for siRNA target identification and validation, mechanism of action studies, biodistribution and biomarker analysis is a plus.
• Strong understanding of ex-hepatic delivery of siRNA is highly desirable.
• Proven ability to develop, troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput.
• Highly self-motivated and capable of thriving in a fast-paced, collaborative team environment.
• Strong written and verbal communication skills, with experience contributing to technical reports, publications, or regulatory documentation.

Why AbbVie?
AbbVie is a global biopharmaceutical company committed to bringing innovative medicines to patients in need. We offer a collaborative work environment, opportunities for professional growth, and the ability to make an impact on the future of healthcare. Join us and be part of a team that is transforming the landscape of genetic medicine.

How to Apply
If you are passionate about advancing RNA-based therapeutics and have a track record of success in cell and molecular biology, we encourage you to apply! Please submit your resume outlining your relevant experience and why you would be a great fit for this position.