Principal Research Scientist I, siRNA Platform Automation

AbbVie’s Biotherapeutics and Genetic Medicine (BGM) department is seeking a highly motivated Principal Research Scientist to join our expanding siRNA team. In this role, you will partner with genetic medicine teams to establish a high-throughput siRNA screening platform that advances pipeline innovation through next-generation delivery modalities and supports the discovery of therapeutic leads across multiple disease areas. 

Responsibilities:

• Establish and implement a high-throughput siRNA screening platform using automated liquid-handling systems. 
• Serve as a subject matter expert in siRNA screening experimental design, execution, and data interpretation. 
• Lead research efforts and mentor scientists to advance siRNA optimization, including sequence design and novel chemical modifications, across multiple programs. 
• Generate new scientific hypotheses and proposals, improve existing screening workflows, and evaluate emerging technologies in the siRNA field. 
• Communicate clearly and effectively with internal siRNA teams and cross-functional collaborators to identify needs and support platform enhancement and program advancement. 
• Manage and develop a team of at least 2-3 scientists, providing technical guidance, mentorship, and day-to-day leadership to support program goals. 

• BS, MS, or PhD in Molecular Biology, Biochemistry, Chemical Biology, or a related field, with typically 6+ years (PhD), 12+ years (MS), or 14+ years (BS) of relevant experience in biotech or pharma.
• Proven track record in siRNA design, in vitro screening, and potency assays with experience using automated high-throughput platforms (e.g., Hamilton, Tecan).
• Experience with assays including, but not limited to, qRT-PCR, ELISA, and flow cytometry.
• Demonstrated experience in cell culture, including the maintenance of diverse cell lines.
• Prior experience leading siRNA platform initiatives or portfolio programs.
• Experience in animal study design and downstream assays to evaluate genetic medicines is a plus.
• Exceptional interpersonal skills and the ability to build productive working relationships with diverse internal teams and external collaborators.
• Strong track record of presenting complex scientific data to internal and external stakeholders.
• Prior people management experience is a plus.