Principal Research Scientist I, siRNA Synthesis & Analytical Development

The Biotherapeutics and Genetic Medicine (BGM) department at AbbVie is seeking a motivated Principal Research Scientist to join the growing siRNA team. In this role, you will work with the genetic medicine teams to establish siRNA synthesis, purification, and analytical capabilities. You will serve as a subject matter expert in oligonucleotide chemistry and siRNA production, with responsibility for generating high-quality siRNA materials to advance genetic medicine studies.

Responsibilities: 

• Lead the siRNA synthesis platform to support various stages of siRNA studies. 
• Oversee solid-phase oligonucleotide synthesis, deprotection, purification, desalting, and analytical characterization of siRNA. 
• Troubleshoot synthesis, purification, and analytical challenges to improve yield, purity, and scalability. 
• Partner with cross-functional teams, including the siRNA screening team, the antibody conjugation group, and CMC, to support platform and project objectives. 
• Ensure rigorous documentation, data integrity, and compliance with internal quality standards. 
• Track and evaluate emerging technologies and best practices in oligonucleotide and RNA-based therapeutics. 
• Manage and develop a team of 2–3 scientists to support program goals and deliver high-quality siRNA materials on time.

• BS, MS, or PhD in chemistry, chemical biology, biochemistry, or a related field, with typically 6+ (PhD), 12+ (MS), or 14+ (BS) years of experience in biotech or pharma.
• Demonstrated expertise in siRNA synthesis, purification, and characterization.
• Strong knowledge of oligonucleotide chemistry, RNA chemistry, conjugation chemistry, and analytical techniques such as HPLC, LC-MS, and UV spectroscopy.
• Demonstrated ability to independently address complex technical problems and drive projects forward.
• Excellent communication, collaboration, and organizational skills.
• Strong track record of presenting complex scientific data to internal and external stakeholders.
• Prior people management experience is a plus.